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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737488
Species: Mus musculus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngdecreases expressionEXP 6480464CTDpirinixic acid results in decreased expression of IFNG mRNAPMID:17888025 PMID:18249437
Ifngmultiple interactionsEXP 6480464CTD[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IFNG protein; pirinixic acid inhibits the reaction [Cisplatin results in increased expression of IFNG mRNA]; PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IFNG protein]PMID:15814532 PMID:17371993
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