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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:104736480464CTDpirinixic acid affects the expression of NQO1 mRNA

PMID:19136022
decreases expressionISORGD:25036480464CTDpirinixic acid results in decreased expression of NQO1 mRNA

PMID:19162173
increases expressionISORGD:104736480464CTDpirinixic acid results in increased expression of NQO1 mRNA

PMID:17950772, PMID:18301758, PMID:20059764, PMID:20813756, PMID:23811191
increases expressionISORGD:25036480464CTDpirinixic acid results in increased expression of NQO1 mRNA

PMID:15890375
multiple interactionsISORGD:104736480464CTDPPARA protein promotes the reaction [pirinixic acid results in increased expression of NQO1 mRNA]

PMID:17950772, PMID:20059764
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