GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP1A2 | multiple interactions | EXP | | 6480464 | CTD | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP1A2 mRNA | PMID:19710929 | CYP1A2 | decreases expression | ISO | Cyp1a2 (Mus musculus) | 6480464 | CTD | pirinixic acid results in decreased expression of CYP1A2 mRNA | PMID:17962186 PMID:18467677 PMID:20059764 PMID:20813756 PMID:23811191 PMID:28541575 | CYP1A2 | decreases expression | ISO | Cyp1a2 (Rattus norvegicus) | 6480464 | CTD | pirinixic acid results in decreased expression of CYP1A2 mRNA | PMID:19162173 | CYP1A2 | multiple interactions | ISO | Cyp1a2 (Mus musculus) | 6480464 | CTD | [pirinixic acid co-treated with PPARA] results in decreased expression of CYP1A2 mRNA; pirinixic acid inhibits the reaction [Phenobarbital results in increased expression of CYP1A2 mRNA]; PPARA protein promotes the reaction [pirinixic acid results in decreased expression of CYP1A2 mRNA] | PMID:17962186 PMID:18467677 PMID:20059764 PMID:20813756 | |
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