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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733179
Species: Homo sapiens
RGD Object: Gene
Symbol: CCNB1
Name: cyclin B1
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCNB1multiple interactionsEXP 6480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CCNB1 mRNAPMID:19710929
CCNB1increases expressionISOCcnb1 (Rattus norvegicus)6480464CTDpirinixic acid results in increased expression of CCNB1 mRNAPMID:12832660 PMID:15890375 PMID:19162173 PMID:22484513
CCNB1increases expressionISOCcnb1 (Mus musculus)6480464CTDpirinixic acid results in increased expression of CCNB1 mRNA; pirinixic acid results in increased expression of CCNB1 proteinPMID:17483499 PMID:18301758 PMID:19176532 PMID:19748123
CCNB1multiple interactionsISOCcnb1 (Mus musculus)6480464CTD[pirinixic acid co-treated with Pregnenolone Carbonitrile] results in increased expression of CCNB1 mRNA; NCF1 protein affects the reaction [pirinixic acid results in increased expression of CCNB1 protein]; PPARA protein affects the reaction [pirinixic acid results in increased expression of CCNB1 protein]; RXRA protein promotes the reaction [pirinixic acid results in increased expression of CCNB1 mRNA]PMID:17483499 PMID:19176532 PMID:23626729
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