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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69401
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acsl4
Name: acyl-CoA synthetase long-chain family member 4
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDpirinixic acid results in increased expression of ACSL4 mRNA

PMID:19162173
increases expressionISORGD:694446480464CTDpirinixic acid results in increased expression of ACSL4 mRNA

PMID:17118139, PMID:17950772, PMID:18301758, PMID:18467677, PMID:20813756
multiple interactionsISORGD:694446480464CTD[pirinixic acid co-treated with PPARA] results in increased expression of ACSL4 mRNA, PPARA protein promotes the reaction [pirinixic acid results in increased expression of ACSL4 mRNA]

PMID:17950772, PMID:18467677, PMID:20813756
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.