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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69210
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP7A1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP7A1decreases expressionEXP 6480464CTDpirinixic acid results in decreased expression of CYP7A1 mRNAPMID:31676336
CYP7A1decreases expressionISOCyp7a1 (Mus musculus)6480464CTDpirinixic acid results in decreased expression of CYP7A1 mRNAPMID:15777286 PMID:18445702 PMID:20059764 PMID:20813756 PMID:20936131 PMID:23811191
CYP7A1increases expressionISOCyp7a1 (Mus musculus)6480464CTDpirinixic acid results in increased expression of CYP7A1 mRNAPMID:20936131
CYP7A1multiple interactionsISOCyp7a1 (Mus musculus)6480464CTDPPARA protein affects the reaction [pirinixic acid results in decreased expression of CYP7A1 mRNA]; PPARA protein promotes the reaction [pirinixic acid results in decreased expression of CYP7A1 mRNA]PMID:15777286 PMID:20059764 PMID:20936131
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