GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ucp2 | increases expression | EXP | | 6480464 | CTD | pirinixic acid results in increased expression of UCP2 mRNA; pirinixic acid results in increased expression of UCP2 protein | PMID:11056218 PMID:16306350 PMID:16306367 PMID:16357043 PMID:16985257 PMID:17426115 PMID:18301758 PMID:20813756 PMID:23811191 | Ucp2 | multiple interactions | EXP | | 6480464 | CTD | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA; [pirinixic acid co-treated with PPARA] results in increased expression of UCP2 mRNA; [pirinixic acid co-treated with Rosiglitazone] results in increased expression of UCP2 mRNA; etomoxir promotes the reaction [pirinixic acid results in increased expression of UCP2 protein]; PPARA protein affects the reaction [pirinixic acid results in increased expression of UCP2 protein] | PMID:16306350 PMID:16306367 PMID:19710929 PMID:20813756 | Ucp2 | affects response to substance | ISO | Ucp2 (Rattus norvegicus) | 6480464 | CTD | UCP2 protein affects the susceptibility to pirinixic acid | PMID:16782780 | Ucp2 | increases expression | ISO | Ucp2 (Rattus norvegicus) | 6480464 | CTD | pirinixic acid results in increased expression of UCP2 mRNA; pirinixic acid results in increased expression of UCP2 protein | PMID:16782780 PMID:18183618 PMID:19162173 PMID:19361538 PMID:32741897 | Ucp2 | multiple interactions | ISO | Ucp2 (Rattus norvegicus) | 6480464 | CTD | [[pirinixic acid results in increased expression of UCP2 protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Potassium Cyanide; [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide] which results in decreased expression of BCL2 protein; [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA; [pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide; [pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein; Acetylcysteine inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]; dihydroxy-vitamin D3 inhibits the reaction [pirinixic acid promotes the reaction [Potassium Cyanide results in increased expression of UCP2 protein]]; Glutathione inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide]; lactacystin inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]; MK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 mRNA]; MK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]; phenyl-N-tert-butylnitrone inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]; pirinixic acid promotes the reaction [Potassium Cyanide results in increased expression of UCP2 protein]; Potassium Cyanide promotes the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide]; Potassium Cyanide promotes the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]; PPARA protein affects the reaction [pirinixic acid results in increased expression of UCP2 mRNA]; PPARA protein affects the reaction [pirinixic acid results in increased expression of UCP2 protein]; SN50 peptide inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein] | PMID:11341955 PMID:16782780 PMID:18183618 PMID:19361538 | | ||||||||||||||||||||||
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