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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp4a1
Name: cytochrome P450, family 4, subfamily a, polypeptide 1
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp4a1increases expressionEXP 6480464CTDpirinixic acid results in increased expression of CYP4A1 mRNA; pirinixic acid results in increased expression of CYP4A1 proteinPMID:15635043 PMID:16940010 PMID:17126302 PMID:19162173 PMID:19647067 PMID:19850644 PMID:20614104 PMID:22112501 PMID:22245121 PMID:26168851 PMID:27665778 PMID:32741897
Cyp4a1multiple interactionsEXP 6480464CTD[pirinixic acid results in increased activity of PPARA protein] which results in increased expression of CYP4A1 mRNA; MDM2 protein promotes the reaction [[pirinixic acid results in increased activity of PPARA protein] which results in increased expression of CYP4A1 mRNA]; perfluorododecanoic acid inhibits the reaction [pirinixic acid results in increased expression of CYP4A1 mRNA]PMID:19103650 PMID:26168851
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