GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Fasn | increases expression | EXP | | 6480464 | CTD | pirinixic acid results in increased expression of FASN mRNA | PMID:19162173 | Fasn | multiple interactions | EXP | | 6480464 | CTD | [[[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased localization of and results in decreased activity of SREBF1 protein] which results in decreased expression of FASN mRNA] which results in decreased abundance of Triglycerides | PMID:19248225 | Fasn | decreases expression | ISO | Fasn (Mus musculus) | 6480464 | CTD | pirinixic acid results in decreased expression of FASN mRNA | PMID:18620774 PMID:23811191 | Fasn | increases expression | ISO | Fasn (Mus musculus) | 6480464 | CTD | pirinixic acid results in increased expression of FASN mRNA | PMID:15302862 PMID:15375163 PMID:15777286 PMID:17118139 PMID:18301758 PMID:20059764 PMID:28049043 | Fasn | multiple interactions | ISO | Fasn (Mus musculus) | 6480464 | CTD | Ethanol inhibits the reaction [pirinixic acid results in decreased expression of FASN mRNA]; PPARA protein affects the reaction [pirinixic acid results in increased expression of FASN mRNA]; PPARA protein promotes the reaction [pirinixic acid results in increased expression of FASN mRNA] | PMID:15777286 PMID:18620774 PMID:20059764 | | ||||||||||||||||||||||
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