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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDpirinixic acid affects the expression of CYP2D4 mRNA

PMID:19483382
decreases expressionEXP 6480464CTDpirinixic acid results in decreased expression of CYP2D4 mRNA

PMID:19162173
decreases expressionISORGD:7362186480464CTDpirinixic acid results in decreased expression of CYP2D22 mRNA

PMID:20813756
increases expressionISORGD:7362186480464CTDpirinixic acid results in increased expression of CYP2D22 mRNA

PMID:17426115
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.