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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:104586480464CTDpirinixic acid results in decreased expression of CYP7A1 mRNA

PMID:15777286, PMID:18445702, PMID:20059764, PMID:20813756, PMID:20936131, PMID:23811191
increases expressionISORGD:104586480464CTDpirinixic acid results in increased expression of CYP7A1 mRNA

PMID:20936131
multiple interactionsISORGD:104586480464CTDPPARA protein affects the reaction [pirinixic acid results in decreased expression of CYP7A1 mRNA], PPARA protein promotes the reaction [pirinixic acid results in decreased expression of CYP7A1 mRNA]

PMID:15777286, PMID:20059764, PMID:20936131
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.