Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1343759
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL1
Name: C-X-C motif chemokine ligand 1
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL1affects expressionISOCxcl3 (Mus musculus)6480464CTDpirinixic acid affects the expression of CXCL1 mRNAPMID:18445702
CXCL1decreases expressionISOCxcl3 (Mus musculus)6480464CTDpirinixic acid results in decreased expression of CXCL1 mRNAPMID:20059764 PMID:20813756
CXCL1decreases expressionISOCxcl1 (Rattus norvegicus)6480464CTDpirinixic acid results in decreased expression of CXCL1 mRNAPMID:19162173
CXCL1increases expressionISOCxcl3 (Mus musculus)6480464CTDpirinixic acid results in increased expression of CXCL1 mRNAPMID:8764118
CXCL1multiple interactionsISOCxcl3 (Mus musculus)6480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CXCL1 mRNA; pirinixic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA]; PPARA protein affects the reaction [pirinixic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA]]; PPARA protein promotes the reaction [pirinixic acid results in decreased expression of CXCL1 mRNA]PMID:19710929 PMID:20059764 PMID:27853831
Go Back to source page   Continue to Ontology report