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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1316883
Species: Mus musculus
RGD Object: Gene
Symbol: Fbxo8
Name: F-box protein 8
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDpirinixic acid results in decreased expression of FBXO8 mRNA

PMID:20813756
multiple interactionsEXP 6480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FBXO8 mRNA

PMID:19710929
multiple interactionsISORGD:13168826480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FBXO8 mRNA

PMID:19710929
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.