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RGD ID: 1316856
Species: Homo sapiens
RGD Object: Gene
Symbol: FBXO4
Name: F-box protein 4
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FBXO4increases expressionISORGD:13168576480464CTDpirinixic acid results in increased expression of FBXO4 mRNA

FBXO4multiple interactionsISORGD:13168576480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FBXO4 mRNA, PPARA protein affects the reaction [pirinixic acid results in increased expression of FBXO4 mRNA]

PMID:19710929, PMID:21318169
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.