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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732272
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:32497
Term: thioacetamide
Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
Chemical ID: MESH:D013853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases expressionISOMapk8 (Rattus norvegicus)6480464CTDThioacetamide results in increased expression of MAPK8 mRNA; Thioacetamide results in increased expression of MAPK8 proteinPMID:34492290 PMID:35961375
Mapk8multiple interactionsISOMapk8 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK8 mRNA; [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of MAPK8 mRNA; Lactulose inhibits the reaction [Thioacetamide results in increased expression of MAPK8 protein]; SB-332235 inhibits the reaction [Thioacetamide results in increased expression of MAPK8 protein]PMID:23830814 PMID:35961375
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