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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Acc ID: CHEBI:32497
Term: thioacetamide
Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
Chemical ID: MESH:D013853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDThioacetamide results in increased expression of COL1A2 mRNA

PMID:10677585
multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of COL1A2 mRNA, HGF protein inhibits the reaction [Thioacetamide results in increased expression of COL1A2 mRNA], Iron, Dietary affects the reaction [Thioacetamide affects the expression of COL1A2 mRNA]

PMID:10677585, PMID:18032466, PMID:28943392
increases expressionISORGD:7309856480464CTDThioacetamide results in increased expression of COL1A2 mRNA

PMID:23408952
multiple interactionsISORGD:7309856480464CTDSPARC protein affects the reaction [Thioacetamide results in increased expression of COL1A2 mRNA]

PMID:23408952
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.