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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:32497
Term: thioacetamide
Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
Chemical ID: MESH:D013853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10decreases expressionEXP 6480464CTDThioacetamide results in decreased expression of IL10 proteinPMID:25051504 PMID:37150287
Il10increases expressionEXP 6480464CTDThioacetamide results in increased expression of IL10 mRNA; Thioacetamide results in increased expression of IL10 proteinPMID:22899499 PMID:26957569 PMID:30883860
Il10multiple interactionsEXP 6480464CTD[Berberine co-treated with Thioacetamide] results in increased expression of IL10 mRNA; Coffee inhibits the reaction [Thioacetamide results in increased expression of IL10 protein]; indole-3-carbinol inhibits the reaction [Thioacetamide results in decreased expression of IL10 protein]; rebaudioside A inhibits the reaction [Thioacetamide results in increased expression of IL10 protein]PMID:22899499 PMID:30138605 PMID:30883860 PMID:37150287
Il10multiple interactionsISOIl10 (Mus musculus)6480464CTDIL10 protein inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]; IL10 protein inhibits the reaction [Thioacetamide results in increased expression of ICAM1 mRNA]; IL10 protein inhibits the reaction [Thioacetamide results in increased expression of PTGS2 protein]; IL10 protein inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; IL10 protein inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA]; IL10 protein inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]; IL10 protein inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA]; IL10 protein inhibits the reaction [Thioacetamide results in increased expression of VCAM1 mRNA]PMID:16126171
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