GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2e1 | decreases activity | EXP | | 6480464 | CTD | Thioacetamide results in decreased activity of CYP2E1 protein | PMID:29763686 | Cyp2e1 | decreases expression | EXP | | 6480464 | CTD | Thioacetamide results in decreased expression of CYP2E1 protein | PMID:27349771 | Cyp2e1 | increases expression | EXP | | 6480464 | CTD | Thioacetamide results in increased expression of CYP2E1 protein | PMID:30625377 | Cyp2e1 | increases metabolic processing | EXP | | 6480464 | CTD | CYP2E1 protein results in increased metabolism of Thioacetamide | PMID:29763686 | Cyp2e1 | increases response to substance | EXP | | 6480464 | CTD | CYP2E1 protein results in increased susceptibility to Thioacetamide | PMID:18374380 | Cyp2e1 | multiple interactions | EXP | | 6480464 | CTD | [CYP2E1 protein results in increased metabolism of Thioacetamide] which results in increased chemical synthesis of thioacetamide-S-oxide; CYP2E1 protein affects the reaction [Thioacetamide results in decreased expression of GPX1 mRNA]; CYP2E1 protein affects the reaction [Thioacetamide results in increased expression of IL6 mRNA]; CYP2E1 protein affects the reaction [Thioacetamide results in increased expression of NOS2 protein]; CYP2E1 protein affects the reaction [Thioacetamide results in increased expression of TNF mRNA] | PMID:18374380 PMID:29763686 | Cyp2e1 | decreases expression | ISO | Cyp2e1 (Rattus norvegicus) | 6480464 | CTD | Thioacetamide results in decreased expression of CYP2E1 mRNA | PMID:16297948 PMID:34492290 | Cyp2e1 | increases activity | ISO | Cyp2e1 (Rattus norvegicus) | 6480464 | CTD | Thioacetamide results in increased activity of CYP2E1 protein | PMID:37150287 | Cyp2e1 | increases expression | ISO | Cyp2e1 (Rattus norvegicus) | 6480464 | CTD | Thioacetamide results in increased expression of CYP2E1 protein | PMID:20036707 | Cyp2e1 | multiple interactions | ISO | Cyp2e1 (Rattus norvegicus) | 6480464 | CTD | [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CYP2E1 mRNA; Eugenol inhibits the reaction [Thioacetamide results in increased expression of CYP2E1 protein]; indole-3-carbinol inhibits the reaction [Thioacetamide results in increased activity of CYP2E1 protein] | PMID:20036707 PMID:28943392 PMID:37150287 | | ||||||||||||||||||||||
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