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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61936
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a2
Name: solute carrier family 22 member 2
Acc ID: CHEBI:3238
Term: butenafine
Definition: Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.
Chemical ID: MESH:C067594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a2multiple interactionsISORGD:13425186480464CTDbutenafine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-4-dimethylaminostyryl-1-methylpyridinium]

PMID:21599003
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