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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1586479
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tslp
Name: thymic stromal lymphopoietin
Acc ID: CHEBI:3238
Term: butenafine
Definition: Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.
Chemical ID: MESH:C067594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tslpmultiple interactionsISORGD:16045566480464CTD4-5H-dibenzoa dcyclohepten-5-ylidene-1-4-2H-tetrazol-5-ylbutylpiperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]] 4-5H-dibenzoa dcyclohepten-5-ylidene-1-4-2H-tetrazol-5-ylbutylpiperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]] butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA] butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]

PMID:23688403
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