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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:3237
Term: butein
Definition: A chalcone that is (E)-chalcone bearing four additional hydroxy substituents at positions 2', 3, 4 and 4'.
Chemical ID: MESH:C040918
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTDbutein affects the reaction [IL6 protein affects the expression of CDH1 protein]; butein affects the reaction [IL6 protein affects the expression of MMP2 protein]; butein affects the reaction [IL6 protein affects the expression of MMP9 protein]; butein affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein]PMID:35130734
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