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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1343759
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL1
Name: C-X-C motif chemokine ligand 1
Acc ID: CHEBI:32269
Term: tropisetron
Definition: An indolyl carboxylate ester obtained by formal condensation of the carboxy group of indole-3-carboxylic acid with the hydroxy group of tropine.
Chemical ID: MESH:C045504
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL1decreases expressionISOCxcl1 (Rattus norvegicus)6480464CTDtropisetron results in decreased expression of CXCL1 proteinPMID:23285267
CXCL1multiple interactionsISOCxcl1 (Rattus norvegicus)6480464CTDchromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein]PMID:23285267
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