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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736066
Species: Homo sapiens
RGD Object: Gene
Symbol: SPP1
Name: secreted phosphoprotein 1
Acc ID: CHEBI:32234
Term: titanium dioxide
Definition: A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.
Chemical ID: MESH:C009495
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SPP1decreases expressionISOSpp1 (Mus musculus)6480464CTDtitanium dioxide results in decreased expression of SPP1 mRNAPMID:29264374
SPP1increases expressionISOSpp1 (Mus musculus)6480464CTDtitanium dioxide results in increased expression of SPP1 mRNAPMID:19464567 PMID:21259345 PMID:23131501 PMID:23557971 PMID:27760801
SPP1increases expressionISOSpp1 (Rattus norvegicus)6480464CTDtitanium dioxide results in increased expression of SPP1 mRNAPMID:30012374
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