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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11055
Species: Mus musculus
RGD Object: Gene
Symbol: Serpine1
Name: serine (or cysteine) peptidase inhibitor, clade E, member 1
Acc ID: CHEBI:32223
Term: tibolone
Definition: Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormone receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.
Chemical ID: MESH:C027385
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpine1increases expressionISOSERPINE1 (Homo sapiens)6480464CTDtibolone metabolite results in increased expression of SERPINE1 protein; tibolone results in increased expression of SERPINE1 proteinPMID:16011840
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