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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737488
Species: Mus musculus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:32181
Term: tamibarotene
Definition: A dicarboxylic acid monoamide resulting from the condensation of one of the carboxy groups of terephthalic acid with the amino group of 5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine.
Chemical ID: MESH:C061133
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngdecreases expressionEXP 6480464CTDtamibarotene results in decreased expression of IFNG; tamibarotene results in decreased expression of IFNG proteinPMID:10828746 PMID:20861477 PMID:22077062
Ifngincreases response to substanceEXP 6480464CTDIFNG results in increased susceptibility to tamibarotenePMID:22077062
Ifngmultiple interactionsEXP 6480464CTDtamibarotene inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG protein]PMID:22077062
Ifngdecreases expressionISOIfng (Rattus norvegicus)6480464CTDtamibarotene results in decreased expression of IFNG mRNAPMID:11043609
Ifngmultiple interactionsISOIfng (Rattus norvegicus)6480464CTDtamibarotene inhibits the reaction [MBP results in increased expression of IFNG mRNA]PMID:11501064
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