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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3282
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdgfa
Name: platelet derived growth factor subunit A
Acc ID: CHEBI:32181
Term: tamibarotene
Definition: A dicarboxylic acid monoamide resulting from the condensation of one of the carboxy groups of terephthalic acid with the amino group of 5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine.
Chemical ID: MESH:C061133
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdgfamultiple interactionsISOPDGFA (Homo sapiens)6480464CTDtamibarotene inhibits the reaction [[KLF5 protein binds to [RARA protein binds to RXRA protein]] which binds to PDGFA promoter]; tamibarotene inhibits the reaction [[RARA co-treated with RXRA] promotes the reaction [KLF5 results in increased expression of PDGFA mRNA]]; tamibarotene inhibits the reaction [KLF5 protein binds to PDGFA promoter]; tamibarotene inhibits the reaction [KLF5 results in increased expression of PDGFA mRNA]; tamibarotene inhibits the reaction [RARA protein binds to PDGFA promoter]; tamibarotene inhibits the reaction [RXRA protein binds to PDGFA promoter]PMID:16224062
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