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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3213
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ntrk2
Name: neurotrophic receptor tyrosine kinase 2
Acc ID: CHEBI:32181
Term: tamibarotene
Definition: A dicarboxylic acid monoamide resulting from the condensation of one of the carboxy groups of terephthalic acid with the amino group of 5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine.
Chemical ID: MESH:C061133
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ntrk2increases expressionEXP 6480464CTDtamibarotene results in increased expression of NTRK2PMID:19182380
Ntrk2increases phosphorylationEXP 6480464CTDtamibarotene results in increased phosphorylation of NTRK2 proteinPMID:19457078
Ntrk2multiple interactionsEXP 6480464CTDBDNF affects the reaction [tamibarotene results in increased phosphorylation of NTRK2 protein]PMID:19457078
Ntrk2multiple interactionsISONTRK2 (Homo sapiens)6480464CTD[tamibarotene co-treated with BDNF] results in increased expression of NTRK2PMID:19182380
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