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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2426
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Csf3
Name: colony stimulating factor 3
Acc ID: CHEBI:32181
Term: tamibarotene
Definition: A dicarboxylic acid monoamide resulting from the condensation of one of the carboxy groups of terephthalic acid with the amino group of 5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine.
Chemical ID: MESH:C061133
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13509556480464CTD[tamibarotene co-treated with CSF3 protein] results in increased expression of CEACAM8 mRNA, CSF3 protein inhibits the reaction [tamibarotene results in decreased expression of ITGB2 mRNA], CSF3 protein inhibits the reaction [tamibarotene results in increased expression of ITGAM mRNA], CSF3 protein promotes the reaction [tamibarotene results in increased expression of CEACAM6 mRNA], CSF3 protein promotes the reaction [tamibarotene results in increased expression of CEBPE mRNA], CSF3 protein promotes the reaction [tamibarotene results in increased expression of RARB mRNA], tamibarotene inhibits the reaction [CSF3 protein results in decreased expression of CEACAM6 mRNA], tamibarotene inhibits the reaction [CSF3 protein results in decreased expression of CEBPE mRNA], tamibarotene inhibits the reaction [CSF3 protein results in increased expression of ITGB2 mRNA], tamibarotene promotes the reaction [CSF3 protein results in increased expression of CEACAM6 mRNA], tamibarotene promotes the reaction [CSF3 protein results in increased expression of CEBPE mRNA], tamibarotene promotes the reaction [CSF3 protein results in increased expression of RARB mRNA]

PMID:27737899
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.