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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733897
Species: Homo sapiens
RGD Object: Gene
Symbol: TH
Name: tyrosine hydroxylase
Acc ID: CHEBI:32168
Term: sulpiride
Definition: A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
Chemical ID: MESH:D013469
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
THincreases activityISOTh (Rattus norvegicus)6480464CTDSulpiride results in increased activity of TH proteinPMID:2884129
THmultiple interactionsISOTh (Mus musculus)6480464CTDSulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of TH protein]PMID:30922767
THmultiple interactionsISOTh (Rattus norvegicus)6480464CTDSulpiride inhibits the reaction [Dopamine results in decreased activity of TH protein]; Sulpiride inhibits the reaction [Rotenone results in decreased expression of TH protein]PMID:18289173 PMID:2884129
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