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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:32168
Term: sulpiride
Definition: A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
Chemical ID: MESH:D013469
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2affects bindingEXP 6480464CTDSulpiride binds to DRD2 proteinPMID:2901473
Drd2decreases activityEXP 6480464CTDSulpiride results in decreased activity of DRD2 proteinPMID:7644023
Drd2increases expressionEXP 6480464CTDSulpiride results in increased expression of DRD2PMID:1351265
Drd2multiple interactionsEXP 6480464CTDMethamphetamine inhibits the reaction [Sulpiride binds to DRD2 protein]; Sulpiride binds to and results in decreased activity of DRD2 protein; Sulpiride inhibits the reaction [Tacrolimus affects the activity of DRD2 protein]PMID:15332494 PMID:2891082 PMID:8774428
Drd2affects bindingISODRD2 (Homo sapiens)6480464CTDSulpiride binds to DRD2 proteinPMID:20361897
Drd2multiple interactionsISODrd2 (Mus musculus)6480464CTD[Sulpiride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to MethamphetaminePMID:20340177
Drd2multiple interactionsISODRD2 (Homo sapiens)6480464CTDSulpiride inhibits the reaction [[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]; Sulpiride inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]PMID:8032591
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