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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353354
Species: Homo sapiens
RGD Object: Gene
Symbol: KCNQ1
Name: potassium voltage-gated channel subfamily Q member 1
Acc ID: CHEBI:3215
Term: bupivacaine
Definition: A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Chemical ID: MESH:D002045
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KCNQ1decreases activityEXP 6480464CTDBupivacaine results in decreased activity of KCNQ1 proteinPMID:16931984
KCNQ1increases response to substanceEXP 6480464CTDKCNQ1 protein mutant form results in increased susceptibility to BupivacainePMID:16931984
KCNQ1multiple interactionsEXP 6480464CTDBupivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]; KCNE1 protein inhibits the reaction [KCNQ1 protein mutant form results in increased susceptibility to Bupivacaine]PMID:16931984
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