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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737323
Species: Homo sapiens
RGD Object: Gene
Symbol: ACE
Name: angiotensin I converting enzyme
Acc ID: CHEBI:32016
Term: pirfenidone
Definition: A pyridone that is 2-pyridone substituted at positions 1 and 5 by phenyl and methyl groups respectively. An anti-inflammatory drug used for the treatment of idiopathic pulmonary fibrosis.
Chemical ID: MESH:C093844
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACEdecreases expressionISOAce (Rattus norvegicus)6480464CTDpirfenidone results in decreased expression of ACE proteinPMID:28091615
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