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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730821
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:32016
Term: pirfenidone
Definition: A pyridone that is 2-pyridone substituted at positions 1 and 5 by phenyl and methyl groups respectively. An anti-inflammatory drug used for the treatment of idiopathic pulmonary fibrosis.
Chemical ID: MESH:C093844
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP2multiple interactionsISOMmp2 (Rattus norvegicus)6480464CTDpirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA]; pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA]]PMID:15571005 PMID:28696894 PMID:28921394
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