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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621676
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acta2
Name: actin alpha 2, smooth muscle
Acc ID: CHEBI:32016
Term: pirfenidone
Definition: A pyridone that is 2-pyridone substituted at positions 1 and 5 by phenyl and methyl groups respectively. An anti-inflammatory drug used for the treatment of idiopathic pulmonary fibrosis.
Chemical ID: MESH:C093844
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta2decreases expressionEXP 6480464CTDpirfenidone results in decreased expression of ACTA2 proteinPMID:28091615
Acta2multiple interactionsEXP 6480464CTDpirfenidone inhibits the reaction [Adenine results in increased expression of ACTA2 mRNA]PMID:28866419
Acta2decreases expressionISOACTA2 (Homo sapiens)6480464CTDpirfenidone results in decreased expression of ACTA2 mRNA; pirfenidone results in decreased expression of ACTA2 proteinPMID:24706986
Acta2multiple interactionsISOActa2 (Mus musculus)6480464CTDpirfenidone inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]PMID:29273418
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