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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10916
Species: Mus musculus
RGD Object: Gene
Symbol: Mpo
Name: myeloperoxidase
Acc ID: CHEBI:31991
Term: phenol red
Definition: 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 4-hydroxyphenyl groups. A pH indicator changing colour from yellow below pH 6.8 to bright pink above pH 8.2, it is commonly used as an indicator in cell cultures and in home swimming pool test kits. It is also used in the (now infrequently performed) phenolsulfonphthalein (PSP) test for estimation of overall blood flow through the kidney.
Chemical ID: MESH:D010637
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mpoincreases oxidationISOMPO (Homo sapiens)6480464CTDMPO protein results in increased oxidation of PhenolsulfonphthaleinPMID:31288001
Mpomultiple interactionsISOMPO (Homo sapiens)6480464CTD[MPO protein results in increased oxidation of Phenolsulfonphthalein] which results in decreased abundance of Glutathione; [MPO protein results in increased oxidation of Phenolsulfonphthalein] which results in increased abundance of Glutathione Disulfide; MPO protein promotes the reaction [Phenolsulfonphthalein binds to Halogens]; Phenolsulfonphthalein promotes the reaction [MPO protein promotes the reaction [chlorodimedone binds to Chlorine]]PMID:31288001
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