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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736493
Species: Homo sapiens
RGD Object: Gene
Symbol: UNC5B
Name: unc-5 netrin receptor B
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:6217566480464CTDoxaliplatin results in increased expression of UNC5B mRNA

PMID:25729387
multiple interactionsISORGD:6217566480464CTD[oxaliplatin co-treated with Topotecan] results in increased expression of UNC5B mRNA

PMID:25729387
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.