GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Vegfa | increases expression | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | oxaliplatin results in increased expression of VEGFA mRNA; oxaliplatin results in increased expression of VEGFA protein | PMID:18790786 | Vegfa | multiple interactions | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | [TYMS enhancer polymorphism co-treated with VEGFA gene SNP] affects the susceptibility to [Capecitabine co-treated with oxaliplatin]; AG 1879 inhibits the reaction [oxaliplatin results in increased expression of VEGFA protein]; Dactinomycin inhibits the reaction [oxaliplatin results in increased expression of VEGFA mRNA]; U 0126 inhibits the reaction [oxaliplatin results in increased expression of VEGFA protein]; wortmannin inhibits the reaction [oxaliplatin results in increased expression of VEGFA protein] | PMID:18790786 PMID:21048041 | | ||||||||||||||||||||||
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