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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc31a1
Name: solute carrier family 31 member 1
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc31a1decreases expressionEXP 6480464CTDoxaliplatin results in decreased expression of SLC31A1 proteinPMID:20836889
Slc31a1increases importEXP 6480464CTDSLC31A1 protein results in increased import of oxaliplatinPMID:23123662
Slc31a1multiple interactionsEXP 6480464CTDcopper histidine inhibits the reaction [SLC31A1 protein results in increased import of oxaliplatin]; Copper inhibits the reaction [SLC31A1 protein results in increased import of oxaliplatin]PMID:23123662 PMID:23556474
Slc31a1affects response to substanceISOSLC31A1 (Homo sapiens)6480464CTDSLC31A1 protein affects the susceptibility to oxaliplatinPMID:16773204
Slc31a1decreases response to substanceISOSlc31a1 (Mus musculus)6480464CTDSLC31A1 gene mutant form results in decreased susceptibility to oxaliplatinPMID:16847145
Slc31a1increases response to substanceISOSLC31A1 (Homo sapiens)6480464CTDSLC31A1 protein results in increased susceptibility to oxaliplatinPMID:15634647
Slc31a1increases uptakeISOSLC31A1 (Homo sapiens)6480464CTDSLC31A1 protein results in increased uptake of oxaliplatinPMID:15634647
Slc31a1increases uptakeISOSlc31a1 (Mus musculus)6480464CTDSLC31A1 protein results in increased uptake of oxaliplatinPMID:16847145
Slc31a1multiple interactionsISOSLC31A1 (Homo sapiens)6480464CTD[Penicillamine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin; [Trientine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatinPMID:22914438
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