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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619574
Species: Homo sapiens
RGD Object: Gene
Symbol: GFAP
Name: glial fibrillary acidic protein
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GFAPdecreases expressionISOGfap (Rattus norvegicus)6480464CTDoxaliplatin results in decreased expression of GFAP mRNAPMID:25729387
GFAPincreases expressionISOGfap (Rattus norvegicus)6480464CTDOxaliplatin results in increased expression of GFAP proteinPMID:32544411 PMID:36184831
GFAPmultiple interactionsISOGfap (Rattus norvegicus)6480464CTDEmodin inhibits the reaction [Oxaliplatin results in increased expression of GFAP protein]; Lycopene inhibits the reaction [Oxaliplatin results in increased expression of GFAP protein]PMID:32544411 PMID:36184831
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