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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDoxaliplatin results in increased expression of BAX proteinPMID:19428505
Baxmultiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [oxaliplatin results in increased expression of BAX protein]; U 0126 inhibits the reaction [oxaliplatin results in increased expression of BAX protein]PMID:19428505
Baxincreases expressionISOBax (Mus musculus)6480464CTDOxaliplatin results in increased expression of BAX mRNA; Oxaliplatin results in increased expression of BAX proteinPMID:30031110 PMID:36812960
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDoxaliplatin results in increased expression of BAX mRNA; oxaliplatin results in increased expression of BAX proteinPMID:16227409 PMID:23792648
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