GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | H2ax | affects localization | ISO | H2AX (Homo sapiens) | 6480464 | CTD | Oxaliplatin affects the localization of H2AX protein modified form | PMID:19735649 | H2ax | increases expression | ISO | H2AX (Homo sapiens) | 6480464 | CTD | Oxaliplatin results in increased expression of H2AX protein modified form | PMID:19735649 | H2ax | multiple interactions | ISO | H2AX (Homo sapiens) | 6480464 | CTD | [pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form]; MSH3 protein promotes the reaction [Oxaliplatin results in increased phosphorylation of and affects the localization of H2AX protein]; Oxaliplatin promotes the reaction [PARP-1 inhibitor DHC-1 results in increased expression of H2AX protein]; Oxaliplatin results in increased phosphorylation of and affects the localization of H2AX protein; Oxaliplatin results in increased phosphorylation of and results in increased ubiquitination of H2AX protein | PMID:19735649 PMID:21285347 PMID:21750216 PMID:33271260 | H2ax | multiple interactions | ISO | H2ax (Rattus norvegicus) | 6480464 | CTD | [Oxaliplatin co-treated with Topotecan] results in decreased expression of H2AX mRNA | PMID:25729387 | |
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