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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346464
Species: Homo sapiens
RGD Object: Gene
Symbol: H2AX
Name: H2A.X variant histone
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2AXaffects localizationEXP 6480464CTDOxaliplatin affects the localization of H2AX protein modified formPMID:19735649
H2AXincreases expressionEXP 6480464CTDOxaliplatin results in increased expression of H2AX protein modified formPMID:19735649
H2AXmultiple interactionsEXP 6480464CTD[pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form]; MSH3 protein promotes the reaction [Oxaliplatin results in increased phosphorylation of and affects the localization of H2AX protein]; Oxaliplatin promotes the reaction [PARP-1 inhibitor DHC-1 results in increased expression of H2AX protein]; Oxaliplatin results in increased phosphorylation of and affects the localization of H2AX protein; Oxaliplatin results in increased phosphorylation of and results in increased ubiquitination of H2AX proteinPMID:19735649 PMID:21285347 PMID:21750216 PMID:33271260
H2AXmultiple interactionsISOH2ax (Rattus norvegicus)6480464CTD[Oxaliplatin co-treated with Topotecan] results in decreased expression of H2AX mRNAPMID:25729387
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