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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308272
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srpk1
Name: SRSF protein kinase 1
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISORGD:13179506480464CTDSRPK1 protein affects the susceptibility to oxaliplatin

PMID:16773204
increases expressionISORGD:13179506480464CTDoxaliplatin results in increased expression of SRPK1 mRNA

PMID:16773204
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.