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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10215
Species: Mus musculus
RGD Object: Gene
Symbol: Atp7a
Name: ATPase, Cu++ transporting, alpha polypeptide
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp7aaffects response to substanceISOATP7A (Homo sapiens)6480464CTDATP7A protein affects the susceptibility to oxaliplatinPMID:16773204 PMID:17609664
Atp7adecreases response to substanceISOATP7A (Homo sapiens)6480464CTDATP7A protein results in decreased susceptibility to oxaliplatinPMID:25801007
Atp7aincreases expressionISOATP7A (Homo sapiens)6480464CTDoxaliplatin results in increased expression of ATP7A mRNAPMID:16773204
Atp7amultiple interactionsISOATP7A (Homo sapiens)6480464CTD[MIR495 mRNA results in decreased expression of ATP7A protein] which results in increased susceptibility to oxaliplatinPMID:24038379
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