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RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:3193
Term: brucine
Definition: A monoterpenoid indole alkaloid that has formula C23H26N2O4.
Chemical ID: MESH:C083806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1increases activityEXP 6480464CTDbrucine results in increased activity of CYP2E1 proteinPMID:21800547
Cyp2e1multiple interactionsEXP 6480464CTD[brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP2E1 protein; [brucine co-treated with liquiritin] results in decreased activity of CYP2E1 proteinPMID:21800547
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