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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308649
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Elavl1
Name: ELAV like RNA binding protein 1
Acc ID: CHEBI:31882
Term: N-methyl-D-aspartic acid
Definition: An aspartic acid derivative having an N-methyl substituent and D-configuration.
Chemical ID: MESH:D016202
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Elavl1increases phosphorylationISORGD:13185436480464CTDN-Methylaspartate results in increased phosphorylation of ELAVL1 protein

PMID:31945382
Elavl1multiple interactionsISORGD:13185436480464CTD1 2-bis2-aminophenoxyethane N N N' N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein] ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein] ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA] Go 6976 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]

PMID:31945382
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