Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	620784
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Tnfsf11
Name:	TNF superfamily member 11

Acc ID:	CHEBI:31859
Term:	modafinil
Definition:	A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
Chemical ID:	MESH:C048833

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Tnfsf11	increases expression	EXP		6480464	CTD	Modafinil results in increased expression of TNFSF11 mRNA; Modafinil results in increased expression of TNFSF11 protein	PMID:29649498
Tnfsf11	multiple interactions	EXP		6480464	CTD	Alendronate inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; KT 5720 inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Modafinil results in increased expression of TNFSF11 protein]; ZM 241385 inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; ZM 241385 inhibits the reaction [Modafinil results in increased expression of TNFSF11 protein]	PMID:29649498

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