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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3715
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc6a3
Name: solute carrier family 6 member 3
Acc ID: CHEBI:31859
Term: modafinil
Definition: A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
Chemical ID: MESH:C048833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc6a3multiple interactionsEXP 6480464CTDmodafinil inhibits the reaction [SLC6A3 protein affects the uptake of Dopamine]PMID:19197004
Slc6a3affects response to substanceISORGD:7338096480464CTDSLC6A3 gene polymorphism affects the susceptibility to modafinilPMID:24403155
Slc6a3decreases response to substanceISORGD:113156480464CTDSLC6A3 gene mutant form results in decreased susceptibility to modafinilPMID:11222668
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