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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347343
Species: Homo sapiens
RGD Object: Gene
Symbol: TNFSF11
Name: TNF superfamily member 11
Acc ID: CHEBI:31859
Term: modafinil
Definition: A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
Chemical ID: MESH:C048833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFSF11increases expressionISOTnfsf11 (Rattus norvegicus)6480464CTDmodafinil results in increased expression of TNFSF11 mRNA; modafinil results in increased expression of TNFSF11 proteinPMID:29649498
TNFSF11multiple interactionsISOTnfsf11 (Rattus norvegicus)6480464CTDAlendronate inhibits the reaction [modafinil results in increased expression of TNFSF11 mRNA]; KT 5720 inhibits the reaction [modafinil results in increased expression of TNFSF11 mRNA]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [modafinil results in increased expression of TNFSF11 mRNA]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [modafinil results in increased expression of TNFSF11 protein]; ZM 241385 inhibits the reaction [modafinil results in increased expression of TNFSF11 mRNA]; ZM 241385 inhibits the reaction [modafinil results in increased expression of TNFSF11 protein]PMID:29649498
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