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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NQO1decreases expressionEXP 6480464CTDMercuric Chloride results in decreased expression of NQO1 proteinPMID:37172713
NQO1increases expressionEXP 6480464CTDMercuric Chloride results in increased expression of NQO1 mRNAPMID:21843634 PMID:26272509 PMID:27188386
NQO1multiple interactionsEXP 6480464CTD[NOG protein co-treated with Mercuric Chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NQO1 mRNA; Mercuric Chloride promotes the reaction [sulforaphane results in increased expression of and results in increased activity of NQO1 protein]; Mercuric Chloride promotes the reaction [sulforaphane results in increased expression of NQO1 mRNA]; Mercuric Chloride promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of NQO1 protein]; Mercuric Chloride promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; Mercuric Chloride results in increased expression of and results in increased activity of NQO1 protein; NFE2L2 mRNA affects the reaction [Mercuric Chloride results in increased activity of NQO1 protein]; NFE2L2 mRNA affects the reaction [Mercuric Chloride results in increased expression of NQO1 mRNA]PMID:21843634 PMID:27188386
NQO1decreases expressionISONqo1 (Mus musculus)6480464CTDMercuric Chloride results in decreased expression of NQO1 mRNA; Mercuric Chloride results in decreased expression of NQO1 proteinPMID:23202902 PMID:37172713
NQO1increases activityISONqo1 (Mus musculus)6480464CTDMercuric Chloride results in increased activity of NQO1 proteinPMID:18838692
NQO1multiple interactionsISONqo1 (Mus musculus)6480464CTD[Dimercaprol co-treated with Mercuric Chloride] results in increased activity of NQO1 proteinPMID:18838692
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